Joseph loscalzo biography
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We are interested in the redox determinants of normal and abnormal blood vessel function and phenotype. Our specific focus has been on nitric oxide as an endothelial product that is susceptible to oxidative inactivation, the thiol proteome and its oxidative posttranslational modification, and the molecular responses of the endothelial cell to hypoxia.
Nitric oxide is a free radical that reacts readily with a variety of molecules in the vascular milieu to effect its biologic actions.
Joseph loscalzo biography
Chief among these are molecules bearing thiol functionalities which, in the presence of molecular oxygen, lead to the formation of S-nitrosothiols or thionitrites. The unique biologic actions of these naturally occurring nitric oxide adducts have served as a major focus of the laboratory's research efforts.
Both low-molecular-weight and protein thiols react with nitric oxide to form the corresponding S-nitrosothiols; modification of protein thiols in this manner represents a form of post-translational